THE ABBV-CLS-484 DIARIES

Single-cell RNAseq analyses of tumor-infiltrating immune cells verified activation of T cells and shown switching of myeloid-derived suppressor cells in the direction of a proinflammatory phenotype, therefore revealing a definite system of action of ABBV-CLS-484 in contrast with PD-one blockade. Our results demonstrate that PTPN2/N1 inhibitors have